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However, rapid weight loss or very low caloric intake during early treatment phases may temporarily suppress libido due to energy conservation mechanisms in the body

They have not been evaluated in large clinical trials, however

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Simple carbohydrates like sugar, white bread, and refined grains cause rapid blood sugar spikes followed by crashes that trigger hunger
Most of this is water weight and glycogen depletion, not fat loss

Coadministered Cagrilintide and Semaglutide in Adults with Overweight or Obesity (REDEFINE 1)
