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99 Short-acting GLP-1RAs, regarded as postprandial GLP-1, are typically used as add-on therapy for T2DM

In fact, the omitted study was a pooled analysis of 5 RCTs 196,197,198,199,200 of 5,325 patients with obesity followed for up to 3 years, which had shown that liraglutide was no different from placebo for depressive symptoms as scored on the Patient Health Questionnaire-9, while also highlighting a small increased risk of suicidal behavior 193

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None of these clusters are specific to semaglutide- or vehicle-treated HFpEF conditions ( Figure S5B-C ), indicating that semaglutide treatment does not alter the cardiac fibroblast transcriptome to the extent that sample integration, PCA, and Louvain clustering would produce a condition-specific cluster of cardiac fibroblasts

You will work closely with Rachel Snyder, APRN, CNP, to adjust your dosing as needed to facilitate weight loss and avoid plateaus
