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Semaglutide can be combined with certain supplements, but drug interactions and individual health factors require careful evaluation

Conclusions Using GLP-1RAs versus insulin for type 2 diabetes patients requiring intensified injection therapy in clinical practice is cost-effective.

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A double-blind clinical trial shows promising results.

But human observational evidence is increasingly reassuring on major malformations when confounding is handled carefullyfor example, large datasets show no substantial increased risk of major congenital malformations with early exposure, and a European teratology cohort reported no increase in major birth defects vs diabetes/high-BMI comparators