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Key Takeaways Retatrutide is an investigational weight-loss drug showing strong results in trials, but it is not FDA-approved yet

Key contributing factors include advancing age, long-standing disease duration, and suboptimal glycemic control, as well as insulin resistance and androgen deficiencythe latter being particularly common in men with type 2 diabetes (T2D) and obesity

Counterintuitively, yes

Maintaining muscle protein synthesis during a caloric deficit is always beneficial, and resistance training has well-established cardiovascular benefits that I write about regularly

Accessed on May 14, 2025 at MedlinePlus

Randomised, phase 1, dose-finding study of MEDI4166, a PCSK9 antibody and GLP-1 analogue fusion molecule, in overweight or obese patients with type 2 diabetes mellitus