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In contrast to the case reports on altered renal function seen with exenatide, a pooled analysis of 5,594 participants from 19 randomized, controlled clinical trials of exenatide twice-daily (5 g and 10 g) showed that renal impairment-related adverse events, including acute renal failure, were rare (1.6 per 100 person-years for both groups)

Diabetic GLP1s are covered on tier 2 with a PA

Additional subgroup- and sensitivity analyses yielded results similar to the main analysis

GLP-1 agonists are currently approved for three conditions: type 2 diabetes, obesity, and heart disease

Many have advocated that the associations between low mood, suicidal behavior and anti-obesity drugs such as GLP-1RAs are confounded by the pre-existing higher prevalence of neuropsychiatric disorders observed in people living with obesity compared with the general population 236

The obesity GLP-1 market is experiencing rapid growth due to the rising prevalence of obesity and the increasing demand for effective non-surgical weight management solutions