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The platform enables several strategic opportunities, including the following: Lifecycle extension and differentiation Improved benefit-risk profile Scalable platform across CNS indications Building on a validated nose-to-brain platform The new in vivo study results build on MetP Pharmas extensive preclinical body of evidence demonstrating rapid and sustained CNS exposure of GLP-1based therapeutics using its proprietary nasal technologies

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124 Whilst there have been suggestions of a potential association with intestinal obstruction, 125 a Danish health registry analysis of 4430 patients with IBD found no increased risk of bowel obstruction or ileus associated with GLP-1RA

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99 , 9991009 (2021) H.J.L

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