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Tirzepatide was generally well tolerated, with GI issues such as decreased appetite, nausea, and diarrhea being the most common adverse events
Headache was reported as an adverse event during treatment with liraglutide, semaglutide, phentermine/topiramate, and naltrexone/bupropion, though it was not a severe adverse event

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There is a boxed warning for thyroid C-cell tumors, based on rodent studies

How to Get Back on Your Semaglutide Schedule Consistency matters more than perfection when taking semaglutide once weekly

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