novo nordisk's wegovy reduces cardiovascular risk more than lilly's tirzepatide Trial confirms heart benefits of Wegovy, but is weight loss responsible – or something else? The rise, fall and rise

Although total lean mass (baseline 51.3 kg) was also reduced by 2.3 kg and 1.5 kg with semaglutide and canagliflozin, respectively (estimated treatment difference: 0.78 [1.61, 0.04]), the proportion of lean mass (baseline 59.4%) increased by 1.2%- and 1.1%-point, respectively (estimated treatment difference 0.14 [0.89, 1.17])

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Methods Arm-level data from phase III randomized controlled trials of semaglutide (SUSTAIN, STEP) and tirzepatide (SURPASS, SURMOUNT-2) in T2DM were analyzed

Symptomatic post-bariatric hypoglycemia (#PBH) affects ~8% of people who have undergone bariatric surgery