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1 More recently, additional pathophysiologic mechanisms have been identified that are implicated in contributing to impaired glucose homeostasis and the varied metabolic alterations associated with T2DM

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Effectiveness of glucose-lowering medications on cardiovascular outcomes in patients with type 2 diabetes at moderate cardiovascular risk

Described as a disorder of glucose homeostasis and insulin sensitivity, it is primarily triggered by uncontrolled hyperglycemia, and it is responsible for a large number of microvascular (like diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy) and macrovascular complications (like diabetic foot syndrome, cerebrovascular events, and myocardial infarction) [5]

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By contrast the longer GLP-1 (1-37) peptide did not stimulate insulin release from the perfused rat pancreas even at high non-physiological concentrations