negative side effects of glp 1 agonists GI Adverse Glucagon-Like Peptide-1 Receptor GLP-1 Side Effects: A Complete
Description
Most notably, the highest dose of retatrutide (12 mg) led to 24.2% weight loss (vs 2.1% with placebo) at 48 weeks
Interestingly, higher incidence of diabetic retinopathy (DR) complications was noted in patients taking semaglutide (3.0%) compared to placebo (1.5%) in clinical trials, with greater risk in those with a history of DR [32]
Global Overview of the Epidemiology of Atherosclerotic Cardiovascular Disease
Mueller-Gomez, J.L
GLP-1s can also cause gastrointestinal issues such as nausea and vomiting, which may cause some people to discontinue use due to side effects before achieving their weight-loss goals
The need for improved efficacy and fewer side effects also potentiates the development of novel drugs
