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Combining with DPP-4 inhibitors is generally not recommended, as both drug classes work on the incretin system Adding basal insulin for those with more significant hyperglycaemia, which can be used alongside GLP-1 medications (with careful monitoring for hypoglycaemia) Switching to insulin therapy entirely may be necessary for those with advanced beta cell failure For weight management , when GLP-1 medications don't produce adequate weight loss, alternatives include: Orlistat , a lipase inhibitor that reduces fat absorption, though weight loss is typically modest (2-3 kg on average) Naltrexone-bupropion (Mysimba), which works on appetite centres through different pathways

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Over the years, medical researchers have introduced several therapeutic agents to curb the epidemic of obesity

Verify Your Insurance Coverage The first step in securing coverage for your GLP-1 medication is to verify whether your insurance plan covers these drugs

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Final Thoughts GLP-1 side effects are common at the start of treatment but are usually mild and temporary