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Pfizer's decision to halt development of the drug came after "a review of the totality of information, including all clinical data generated to date for danuglipron and recent input from regulators," according to a release

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Through studies of mice and rat models, it has been determined that PPG neurons contain projection tracts to various locations on the brain, including primarily the hypothalamus, supraoptic nucleus, and autonomic regions such as the limbic forebrain, portions of the mesolimbic reward system, and other regions involved in learning and memory [47, 50]