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There are very few trials in IIH and the minimal clinically important change for lumbar puncture pressure is not established and may vary with individual patients

Clin Endocrinol (1998) 48:54753

The SURMOUNT clinical trials studied participants for 72 to 88 weeks, and real-world use is expected to continue indefinitely for many patients

20 Moreover, the high amount of visceral fat and epicardial adipose tissue (EAT), as well as associated plasma volume expansion, in obese individuals results in significant haemodynamic impairment at rest and during exercise, exerting local effects on the heart

J Clin Gastroenterol 2004;38:549557
