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Description

GLP-1 receptor agonists exert neuroprotective effects primarily by inhibiting microglial activation, the primary effector cells of neuroinflammation, thus reducing the production of proinflammatory cytokines (e.g., TNF- , IL-1) and alleviating inflammatory damage to brain parenchyma

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MASH (metabolic dysfunction-associated steatohepatitis, previously NASH) is a more advanced stage where fat buildup causes inflammation and liver cell damage, which can progress to fibrosis or cirrhosis

I suspect this improvement is multifactorial because diabetic patients feel better overall once their blood sugar is more adequately controlled, and obese patients find improved musculoskeletal symptoms and body image thoughts as they lose weight on these medications

The current report, in demonstrating both a consistent glycemic lowering with semaglutide treatment and a consistent safety profile with the GLP-1RA class in the setting of CKD, is important in the context of the potential greater use of such therapies in nephrology-focused clinical practice