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During HBV-associated hepatocarcinogenesis, HSPA8 inhibits ferroptosis by upregulating SLC7A11 and GPX4 , thereby reducing erastin-induced ROS and Fe 2+ accumulation

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Support for Sustainable Weight Loss Unlike restrictive diets, tirzepatide helps reduce caloric intake naturally, without feelings of deprivation

Moreover, GIP has been found to boost glucose uptake by improving insulin sensitivity in adipocytes (176, 177), while tirzepatide has been demonstrated to enhance insulin sensitivity and promote glucose disposal in white adipose tissue in Glp-1r-null mice (178), further supporting a direct effect of GIP on adipose tissues