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The primary mechanism of action involves: Stimulating insulin secretion in a glucose-dependent manner Suppressing glucagon release when blood glucose is elevated Slowing gastric emptying to promote satiety Acting on central nervous system pathways that regulate appetite For type 2 diabetes, these medications typically reduce hemoglobin A1c by 1.01.5%

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Abstract Gastroparesis is characterized by delayed gastric emptying, with symptoms such as nausea, vomiting and abdominal pain, in the absence of mechanical obstruction