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They were randomly assigned to either continue on DPP-4 inhibitors (DPP-4 inhibitor group) or switch to oral semaglutide at 3 mg/day, with a dose increase to 7 mg/day after 4 weeks (semaglutide group)

Same doses

Maintaining Weight Loss After Tirzepatide: Long-Term Success Strategies Discontinuing tirzepatide without lifestyle reinforcement typically results in weight regain within 12 months, as appetite regulation and metabolic rate return to baseline biology

However, since both can irritate the stomach and affect the kidneys, it is important to use the lowest effective dose for the shortest time possible

For ongoing support, patients can benefit from joining support networks and groups that provide both emotional and practical advice