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Campbell JE, Drucker DJ (2013) Pharmacology, physiology, and mechanisms of incretin hormone action
[DOI] [PubMed] [Google Scholar] 46.Liu J, Conde K, Zhang P, Lilascharoen V, Xu Z, Lim BK, et al
These medications mimic this natural hormone, helping to control blood glucose and support weight loss and weight management
This hormone helps the body release insulin, slows digestion, and reduces appetite
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Orforglipron tucks into a compact pocket in the upper helical bundle, contacting transmembrane helices 1, 2, 3, and 7 plus a key extracellular residue, and not engaging helices 4, 5, and 6 the way the peptide does
