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A handful of small observational studies reported that adding one GLP-1 to another did not improve glycemic control or weight loss beyond monotherapy, while gastrointestinal side effects increased substantially
Patients require close monitoring and preparation for renal replacement therapy
Rifaximin treatment in hepatic encephalopathy

In PIONEER 7, flexible dose adjustment of oral semaglutide was more effective than sitagliptin 100 mg in reducing HbA 1c (ETD: 0.5%
