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Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

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Their mechanisms are as follows: folic acid primarily blocks the ferroptosis process by reducing glutamate levels, while cobalamin exerts a protective effect by inhibiting the sterol regulatory element-binding protein (SREBP) binding protein-1 (SBP-1)/SREBP1 lipogenesis axis and reducing lipid peroxidation (72, 73)

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Both treatments show very similar weight loss results in clinical trials, but Mounjaro is generally considered slightly more effective

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