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Preclinical work on optimized tri-agonists demonstrates "best-of-both-worlds" profiles, achieving greater energy expenditure and deeper weight normalization than GLP-1-only comparators [4]

Microvascular arterial disease of the brain and the heart: a shared pathogenesis

Introduction Despite major advance in treatment, cardiovascular diseases are still one of the leading causes of mortality and morbidity in the world

doi: 10.1161/HYPERTENSIONAHA.120.16876 46 UijlEMirabito ColafellaKMSunYRenLvan VeghelRGarreldsIMet al

Given the reabsorption of renin by proximal tubule cells through megalin, and the broad expression of ACE within the kidney, allowing locally synthetized ANG II independent action, the interference of SGLT-2-i with intrarenal RAS could explain such results

Heather McKenzie is a senior editor at BioSpace
