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Despite the significant burden of disease, effective pharmacological options remain limited, leaving lifestyle interventions based on dietary modification and physical activity as the mainstay of clinical management [6]

The North Carolina State Health Plan provides a striking example of the financial implications involved, estimating that continuing to cover brand GLP-1s for weight loss in 2024 would require increasing premiums by $48.50 per subscriber per month for all members, not just GLP-1 users

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Acknowledgments The figure was constructed using BioRender.com (accessed on 21 December 2023)

Combination therapy with insulin glargine and exenatide: real-world outcomes in patients with type 2 diabetes