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Not surprisingly, a subset of DPP-4 inhibitors evaluated during pre-clinical development were found to suppress DPP-8 and/or DPP-9 activity, causing severe toxicities, including weakened T cell activation and proliferation, impaired preadipocyte differentiation (Han et al., 2015), enlarged lymph nodes, splenomegaly, etc
[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Zander M, Madsbad S, Madsen JL, Holst JJ
[DOI] [PMC free article] [PubMed] [Google Scholar] 27.European Medicines Agency

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Adapting to life after gastric sleeve surgery requires patience and a willingness to make gradual, sustained lifestyle changes

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