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Reference: In Silico Pharmacogenomic Assessment of Glucagon-like Peptide-1 (GLP1) Agonists and the Genetic Addiction Risk Score (GARS) Related Pathways: Implications for Suicidal Ideation and Substance Use Disorder by Alireza Sharafshah, Kai-Uwe Lewandrowski, Mark S

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Endogenous GLP-1 is quickly metabolized into the inactive peptide by dipeptidyl peptidase (DPP)-4, whereas GLP-1R agonists (GLP-1RAs) have a substantially longer plasma half-life than GLP-1 because of their resistance to DPP-4

Heres why thats significant: GLP-1 isnt really a resting hormone

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