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During hyperglycemia, GIP potentiates glucose-induced insulin secretion without exhibiting a glucagonotropic effect (35)

A Nature Medicine analysis of the structural and pharmacological data provided mechanistic context for these outcomes, linking the superior efficacy to the additive contributions of all three receptor pathways [9]

In addition to greatly reducing HbA1c levels, tirzepatide treatment was not associated with increased cardiovascular risk [7, 26]

10.1016/S2213-8587(19)30184-6 8 ArodaV

Asmar A, Simonsen L, Asmar M, Madsbad S, Holst JJ, Frandsen E, et al

4 Gastroparesis, also known as stomach paralysis or delayed gastric emptying, is a condition in which undigested food stays in the stomach for prolonged periods of time and can cause severe nausea, vomiting and severe abdominal pain