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Description

Excess weight is a significant risk factor for various health conditions, including heart disease, high blood pressure, and certain types of cancer

The neurocircuitry underlying feeding control is complex and requires the coordinated involvement of many likely redundant and parallel brain circuits

Abstract Aims/hypothesis The aim of this study was to assess the doseresponse effects of the subcutaneous glucagon receptor/glucagon-like peptide-1 receptor dual agonist survodutide (BI 456906) on HbA 1c levels and bodyweight reduction

We also attempted replication analysis in the UK Biobank cohort, although the available data predate the availability of semaglutide or tirzepatide, and hence relied on earlier variants of GLP1 receptor agonists