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Activation of the GLP-1 receptor initiates a series of cascading reactions, which exert a hypoglycemic effect by stimulating insulin secretion from pancreatic -cells and inhibiting glucagon secretion from -cells, thereby reducing the stimulatory effect of glucagon on gluconeogenesis in the liver (Figure 2)

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Boxed Warning: Risk of Thyroid C-Cell Tumors Tirzepatide caused thyroid C-cell tumors in rats