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Mass compounding of semaglutide the active ingredient in Novo Nordisk's Ozempic and Wegovy needs to stop by the end of May, according to the FDA

Four primary degradation pathways affect tirzepatide, and each one chips away at the peptide in a different way

Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial [published correction appears in Lancet

The combination of these two drugs aims to leverage their complementary mechanisms, maximizing weight loss and metabolic control

A TwinRCTs AI-driven approach takes advantage of high-quality, comprehensive datasets even from failed trials such as Roches GRADUATE program to train machine-learning models that generate precise prognostic digital twins for AD trial patients

SURPASS-CVOT cardiovascular outcomes trial (Nicholls 2025)