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AWARD-7 enrolled adult patients with T2D (A1c, 7.5%10.5%) and CKD stages 34 who were being treated with ACEi or ARBs and found that dulaglutide (0.75 or 1.5 mg subcutaneous once weekly) achieved similar glycemic control to insulin glargine but had significantly less eGFR decline (mean 0.7 vs 3.3 mL/min/1.73 m 2 , respectively
The potential risks to the developing fetus, coupled with the evolving hormonal landscape of pregnancy, underscore the importance of individualized decision-making guided by healthcare professionals
A patient with specific GLP1R polymorphisms might be a candidate for higher doses, while one with particular FTO variants might benefit from combined GLP-1 and GIP activation
Dillon et al
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