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VITAMIN B12 DEFICIENCY Studies have demonstrated that vitamin B12 malabsorption is a side effect of metformin therapy (53)

Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabetes, vol

weight loss at target dose (trial data) ~21% (SURMOUNT) CV risk reduction labelled Under study Format Prefilled KwikPen + single-dose autoinjector India price (May 2026) 14,00027,500/month DCGI-approved Yes (March 2025) Generic competition in India No no Indian biosimilar yet Weight-loss percentages are trial averages at target dose individual response varies

26% of patients achieved more than 30% weight loss compared to 0% on lifestyle changes alone

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As research continues, these medications may become an important tool for managing a wide range of conditions, from metabolic and cardiovascular health to neuroinflammation and mast cell disorders