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Issue 42 of The Altascientist explores GLP-1 receptor agonist drug development, covering preclinical models, bioanalytical assays, clinical study design, and manufacturing

New research suggests that switching to a maintenance dose of GLP-1 medication could help lock in weight loss.

A recent study, published in the Journal of Pharmacy and Pharmacology Research, sugges

Injection-site reactions and worsening of pre-existing diabetic retinopathy are also relevant clinical concerns

Administered as a subcutaneous weekly injection, it is a manifold single pharmacological agent that has the ability to significantly lower glucose levels, as well as improve insulin sensitivity, reduce weight and amend dyslipidemia favorably modifying the lipid profile

Recent advancementsincluding the approval of oral semaglutide (Rybelsus)have demonstrated the potential for effective oral peptide delivery, though such formulations still face significant pharmacokinetic and formulation-related challenges