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The downstream effects include activation of hormone-sensitive lipase in adipose tissue (which breaks down stored triglycerides into free fatty acids), increased protein synthesis in skeletal muscle, enhanced cellular repair and turnover, elevated IGF-1 production from the liver, and improved lipid metabolism including reduced triglycerides

These improvements may prove critical for women with PCOS should GLP-1 medications obtain the appropriate authorisation, as managing weight and insulin resistance can significantly improve overall health and fertility

Publicly funded research agencies like the National Institutes of Health could play an important role by rapidly investigating the most promising uses of GLP-1 drugs, particularly in areas where pharmaceutical companies may be reluctant to invest, such as traumatic brain injury, for which trials are difficult to run

Increased understanding of NASH susceptibility and pathogenesis, emerging human multiomics profiling, integration of electronic health record data and modern pharmacology techniques hold enormous promise in delivering a paradigm shift in antifibrotic drug development in NASH