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SURMOUNT-1 was the landmark study

Nearly two-thirds of people on the highest dose lost more than a fifth of their body weight

Patients should have access to these therapies, said Dr Matthew Klebanoff, assistant professor of internal medicine at the Perelman School of Medicine who has studied prior authorization policies for GLP-1 drugs

Avoid tirzepatide if you have a personal or family history of medullary thyroid carcinoma or MEN 2 (boxed warning), a history of pancreatitis, severe gastrointestinal motility disease, or known hypersensitivity to tirzepatide

This is usually accompanied by: Abdominal cramps Abdominal pain Bloating Nausea Urgent bowel movements 1 Acute diarrhea is the most common form of the condition, usually lasting only one or two days