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Important Safety Information Who should not use tirzepatide: Type 1 diabetes patients (tirzepatide is not approved for type 1 diabetes) History of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

GLP-1 medications help by targeting the underlying mechanisms that regulate appetite and blood sugar levels, without directly impacting muscle tissue

Mod Pathol 28:391402 Monazzam A, Lau J, Velikyan I et al (2018) Increased expression of GLP-1R in proliferating islets of men1 mice is detectable by [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 /PET

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[3] It is important to distinguish correlation from causation

These medications decreased: Heart failure hospitalizations by 10-11% according to meta-analyzes including over 60,000 patients 14