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In DELIGHT, the combination of saxagliptin and dapagliflozin showed potentially additive but marginal albuminuria-lowering effects in T2D subjects ( Conclusion and Perspectives GLP-1RAs are widely used in the treatment of T2D

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Douros A, Filion KB, Yin H, et al

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Mechanism of Action: Step-by-Step Enhanced Insulin Secretion Tirzepatide stimulates glucose-dependent insulin release from pancreatic beta cells

Mechanistically, GLP-1 preserved LV function and LV mass, promoted myocardial glucose utilization, and attenuated cardiomyocyte apoptosis (35)