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A key question is how their spatial restriction is regulated

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Local delivery of the drug can minimize its adverse effects, but due to off-target effects, the effectiveness of Rosi is quite limited

doi: 10.2337/dc18-2028 [DOI] [PMC free article] [PubMed] [Google Scholar] 56

Because this is a recently recognized adverse effect, treatment strategies are drawn from case report outcomes, general allodynia management guidelines, and clinical experience with neuropathic pain