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Tirzepatide is available in weekly subcutaneous doses of 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg (Table 1)

Alternative pharmacotherapy options Beyond GLP-1 RAs, current FDA-approved pharmacotherapies for chronic weight management include orlistat (a lipase inhibitor that reduces fat absorption), phentermine-topiramate (a sympathomimetic appetite suppressant combined with a gamma-aminobutyric acid receptor modulator), naltrexone-bupropion (an opioid antagonist combined with a dopamine/norepinephrine reuptake inhibitor), and setmelanotide (a melanocortin-4 receptor agonist)

The demand for tirzepatide has outpaced supply since its launch, and the search for effective alternatives has become one of the most common questions in weight management and metabolic health research

doi:10.1172/JCI105685 183

A larger phase III trial involving hundreds or thousands of patients would be ideal to confirm these benefits

It's also important to spread your fiber intake evenly throughout the day