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Several mechanisms explain why GLP-1 RAs reduce body weight: Central appetite suppression: GLP-1 receptors in the hypothalamus and brainstem alter hunger signalling and food reward

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GLP-1 receptor agonists are known to suppress appetite, which can lead to a reduced intake of essential micronutrients

Derek Thompson: How long did it take Lilly to recognize that what had begun as a type 2 diabetes drug was in fact an incredibly powerful weight-loss drug

[1] The clinical trial data for semaglutide at the 2.4mg dose used in Wegovy did not identify menstrual irregularities or intermenstrual bleeding as a direct adverse effect of the medication

Participants were tested using the standard Movement Disorder Society-Unified Parkinsons Disease Rating Scale (MDS-UPDRS) part 3 test battery at baseline, after 6 months, and at the studys end