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* The HARMONY 7 trial of albiglutide versus liraglutide (71) has been omitted because albiglutide is no longer available commercially in the United States

The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required

Studies suggest potential applications for GLP-1RAs in reducing obstructive sleep apnea severity, particularly in adolescents with obesity and respiratory issues

doi: 10.1016/j.diabres.2021.108904 [DOI] [PubMed] [Google Scholar] 87.Ma H, H LY, Z DL, et al

Human studies indicate that the insulinotropic action of GIP is blunted in individuals with severe hyperglycemia, in contrast to the intact action of GLP-1

Nevertheless, they could still support healing via mechanisms such as enhanced angiogenesis and keratinocyte migration [99]