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One such challenge is that GLP-1s are designed to be taken for the long-term, however, up to 68% of people have discontinued their treatment as soon as one year later

Special Populations and Considerations Certain subgroups of adolescents may derive particular benefit from GLP-1 RA therapy or require special consideration

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Limited clinical experience and small case reports suggest that semaglutide and other GLP-1 agonists may reduce food preoccupation and support modest weight loss in PWS patients, particularly when combined with behavioral support and structured meal planning