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Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening

In other words, under the influence of GLP-1, individuals feel full sooner, leading to lower appetite and reduced food intake - a perfect recipe for weight loss

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[1] [6] The proposed mechanisms linking these therapies to gallbladder complications include altered gallbladder motility and bile composition changes

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Oral peptide drug delivery is limited by low permeability of the gastrointestinal tract and rapid enzymatic and pH-induced degradation in the stomach