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PMCID: PMC8294388.

While Tirzepatide targets GLP-1 and GIP receptors, Retatrutide goes further by also acting on glucagon receptors, which contributes to its enhanced weight loss effects demonstrated in trials

Just tell them its true

The magnitude remains important

Ozempic does not directly cause vitamin B12 deficiency like metformin does

Using semaglutide and tirzepatide together is less common and carries more risk, but has been explored in clinical practice for refractory cases
