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Description

GLP-1 receptor agonists like semaglutide have shown cardiovascular and renal protective effects in large clinical trials, yet questions persist about their safety in patients with pre-existing kidney disease

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These medications work through several mechanisms simultaneously

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Across STEP 13, we observed that reductions in body weight from baseline to week 68 with semaglutide 2.4 mg were nearly as great in participants without versus with GI AEs: in the descriptive analysis, weight loss with semaglutide 2.4 mg ranged from 9.6% to 17.1% in participants without GI AEs and from 11.4% to 17.7% in those with GI AEs