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A summary of clinically-significant GLP-1RAs described in this text and their clinical uses are listed in Table 1

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however, the prevalence and natural history of diabetic gastroparesis is poorly defined A number of management strategies for patients with type 2 diabetes mellitus specifically target gastric emptying A bidirectional relationship exists between the rate of gastric emptying and glycaemia, such that the rate of gastric emptying is partially modulated by acute changes in blood glucose concentrations In patients with severe diabetic gastroparesis, histological abnormalities are heterogeneous

One area where the Trump administration is aiming to reduce costs is for GLP-1 agonists a class of drugs that includes brand names like Ozempic and Wegovy often used for weight loss and the treatment of diabetes and other chronic conditions

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Real-world data from a 2025 study in Diabetes, Obesity and Metabolism which looked at actual clinical patients rather than trial participants showed tirzepatide patients lost 5.3% of body weight over six months compared to 2.7% with semaglutide