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The August 2023 announcement of topline results was followed in November 2023 by a presentation of detailed results7, which revealed a statistically significant reduction in non-fatal myocardial infarction of 28% and smaller reductions in cardiovascular death and non-fatal stroke which were not statistically significant over the length of the trial (up to five years)

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This approach highlights how nutritional substrates and metabolic cofactors may influence physiological resilience during sustained pharmacological weight reduction