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doi: 10.1016/j.mvr.2012.06.008 83 FujitaHMoriiTFujishimaHSatoTShimizuTHosobaMet al

Maselli, D.B

The two types of incretin hormones that have critical roles in incretin signaling, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), bind to specific members of the G-protein-coupled receptor (GPCR) family: the GLP-1 receptor (GLP-1R) and the GIP receptor (GIPR), respectively

The GLP-1 Revolution: How Next-Generation Obesity Drugs Are Reshaping Global Healthcare Obesity now affects more than 1 billion people globally, making it one of the most urgent public health and pharmaceutical market opportunities of this decade

For type 2 diabetes, NICE recommends GLP-1 agonists when other treatments haven't achieved target HbA1c levels, with specific consideration for cardiovascular and renal risk factors according to NICE guideline NG28

Detailed information on the system can be found in Rathod YD and Di Fulvio M (2021)
