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Those taking GLP1s are more likely to have T2D and hypertension, both risk factors for NAION

Endoplasmic reticulum stress in pancreatic beta cells induces incretin desensitization and beta-cell dysfunction via ATF4-mediated PDE4D expression

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These same receptors exist in reproductive tissues, which means GLP-1 compounds may influence ovulation timing, sperm production, and hormone signaling involved in conception

You are in a significant caloric deficit, potentially losing over a pound per week, and your body composition results depend heavily on whether muscle mass is preserved during that process