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PLoS ONE 7 (1), e30014 (2012)

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The in vivo effects of AT-7687 were evaluated in obese cynomolgus monkeys, and when combined with the GLP-1 analogue liraglutide, AT-7687 enhances weight reduction induced by liraglutide and improves glycemic control and lipid metabolism (51)

One such challenge is that GLP-1s are designed to be taken for the long-term, however, up to 68% of people have discontinued their treatment as soon as one year later

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Association of semaglutide with tobacco use disorder in patients with type 2 diabetes: Target trial emulation using real-world data
