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Description
Dulaglutide utilises a large recombinant fusion protein with Fc fragment for prolonged action, achieving a 5-day half-life with once-weekly dosing [29]
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They are commonly used to treat inflammatory bowel diseases such as UC

de Boer IH, DCCT/EDIC Research Group (2014) Kidney disease and related findings in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

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This difference reflects the brain's adaptation to new satiety patterns over time