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buccal, gingival, sublingual)] or rectal route
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Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors, whereas semaglutide targets only GLP-1 and tirzepatide targets GLP-1 and GIP

J.O'RahillyS.et al

More than a quarter of people with Type 2 diabetes take GLP-1 receptor agonists, but the popular diabetes drugs might not work as well for people who have certain genetic variants, according to a new study by Stanford Medicine scientists and their collaborators
